购物车
帮助
021-54845833/15800441009
中文名称：小鼠抗BRAF单克隆抗体
|
Background: |
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. |
|
Applications: |
WB |
|
Name of antibody: |
BRAF |
|
Immunogen: |
Fusion protein of human BRAF |
|
Full name: |
B-Raf proto-oncogene, serine/threonine kinase |
|
Synonyms: |
NS7; B-raf; BRAF1; RAFB1; B-RAF1 |
|
SwissProt: |
P15056 |
|
WB Predicted band size: |
84 kDa |
|
WB Positive control: |
MDA-MB-468, T47D, MCF7, HCT116, C2C12, 3T3 and Hela cell lysates |
|
WB Recommended dilution: |
1000-5000 |
