兔抗DCC多克隆抗体

Background:

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Applications:

ELISA, IHC

Name of antibody:

DCC

Immunogen:

Synthetic peptide of human DCC

Full name:

deleted in colorectal carcinoma

Synonyms:

CRC18; CRCR1; MRMV1; IGDCC1

SwissProt:

P43146

IHC positive control:

Human gastric cancer and human liver cancer

IHC Recommend dilution:

50-200