兔抗CUL5多克隆抗体

Background:

Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Applications:

ELISA, IHC

Name of antibody:

CUL5

Immunogen:

Fusion protein of human CUL5

Full name:

cullin 5

Synonyms:

CUL-5; VACM1; VACM-1

SwissProt:

Q93034

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human liver cancer

IHC Recommend dilution:

50-200