购物车
帮助
021-54845833/15800441009
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Background: |
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. |
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Applications: |
WB |
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Name of antibody: |
SHARPIN |
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Immunogen: |
Fusion protein of human SHARPIN |
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Full name: |
SHANK associated RH domain interactor |
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Synonyms: |
SIPL1 |
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SwissProt: |
Q9H0F6 |
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WB Predicted band size: |
40 KD |
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WB Positive control: |
Hela, Jurkat, 293T cell lysates |
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WB Recommended dilution: |
500-2000 |
