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Fusion protein corresponding to a region derived from 20-211 amino acids of human GDNF |
技术规格
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Full name: |
glial cell derived neurotrophic factor |
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Synonyms: |
ATF1; ATF2; HSCR3; HFB1-GDNF |
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Swissprot: |
P39905 |
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Gene Accession: |
BC069369 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. |
