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021-54845833/15800441009
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Fusion protein corresponding to C terminal 250 amino acids of human CYP1B1 |
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Full name: |
cytochrome P450, family 1, subfamily B, polypeptide 1 |
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Synonyms: |
CP1B; GLC3A; CYPIB1; P4501B1 |
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Swissprot: |
Q16678 |
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Gene Accession: |
BC012049 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. |
