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  • CASP3抗原(重组蛋白)

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    • 品牌 : 通蔚生物
    • 目录号 : TW9766
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中文名称:CASP3抗原(重组蛋白)

英文名称:
CASP3 Antigen (Recombinant Protein)

储      存:
冷冻(-20℃)

相关类别:抗原

概述

Fusion protein corresponding to N terminal 269 amino acids of human CASP3


技术规格

Full name:

caspase 3, apoptosis-related cysteine peptidase

Synonyms:

CPP32, SCA-1, CPP32B

Swissprot:

P42574

Gene Accession:

BC016926

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.