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英文名称： Anti-IMPA1 rabbit polyclonal antibody
标 记 物： Unconjugate
技术规格
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Background: |
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
IMPA1 |
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Immunogen: |
Fusion protein of human IMPA1 |
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Full name: |
inositol monophosphatase 1 |
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Synonyms: |
IMP; IMPA |
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SwissProt: |
P29218 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer and Human esophagus cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
30 kDa |
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WB Positive control: |
Human cerebrum tissue lysate |
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WB Recommended dilution: |
500-2000 |
