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中文名称：ARRB1抗原（重组蛋白）
英文名称：ARRB1 Antigen (Recombinant Protein)
储 存：冷冻（-20℃）
相关类别：抗原
概述
|
Fusion protein corresponding to a region derived from 46-300 amino acids of human ARRB1 |
技术规格
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Full name: |
arrestin, beta 1 |
|
Synonyms: |
ARB1; ARR1 |
|
Swissprot: |
P49407 |
|
Gene Accession: |
BC003636 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. |
