购物车
帮助
021-54845833/15800441009
中文名称：ANTXR1抗原（重组蛋白）
英文名称：ANTXR1 Antigen (Recombinant Protein)
储 存：冷冻（-20℃）
相关类别：抗原
概述
|
Fusion protein corresponding to a region derived from 1-332 amino acids of human ANTXR1 |
技术规格
|
Full name: |
Anthrax toxin receptor 1 |
|
Synonyms: |
ATR; TEM8 |
|
Swissprot: |
Q9H6X2 |
|
Gene Accession: |
BC012074 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. |
