兔抗IKZF3多克隆抗体

Background:

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Applications:

ELISA, IHC

Name of antibody:

IKZF3

Immunogen:

Fusion protein of human IKZF3

Full name:

IKAROS family zinc finger 3 (Aiolos)

Synonyms：

AIO; AIOLOS; ZNFN1A3

SwissProt:

Q9UKT9

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human liver cancer and human thyroid cancer

IHC Recommend dilution:

50-200