兔抗AANAT多克隆抗体

Background:

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

AANAT

Immunogen:

Fusion protein of human AANAT

Full name:

aralkylamine N-acetyltransferase

Synonyms：

DSPS; SNAT

SwissProt:

Q16613

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human thyroid cancer and Human cervical cancer

IHC Recommend dilution:

50-200