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021-54845833/15800441009
抗 原： IDH2
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
Background:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.
Applications:
ELISA, WB, IHC
Name of antibody:
IDH2
Immunogen:
Fusion protein of human IDH2
Full name:
isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms：
IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH
SwissProt:
P48735
ELISA Recommended dilution:
2000-5000
IHC positive control:
Human cervical cancer and human colon cancer
IHC Recommend dilution:
100-300
WB Predicted band size:
51 kDa
WB Positive control:
Human fetal muscle tissue, Jurkat and 293T cells, Hela cells and mouse liver tissue
WB Recommended dilution:
500-2000
技术规格
