兔抗HSD11B1多克隆抗体

Background:

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Applications:

ELISA, IHC

Name of antibody:

HSD11B1

Immunogen:

Fusion protein of human HSD11B1

Full name:

hydroxysteroid 11-beta dehydrogenase 1

Synonyms:

HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1

SwissProt:

P28845

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and Human liver cancer

IHC Recommend dilution:

50-200