小鼠抗NDUFB9单克隆抗体

Background:

The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants.

Applications:

WB, IHC, FC

Name of antibody:

NDUFB9

Immunogen:

Fusion protein of human NDUFB9

Full name:

NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 1

Synonyms:

B22; CI-B22; LYRM3; UQOR22

SwissProt:

Q9Y6M9

IHC positive control:

human kidney tissue and carcinoma of human liver tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

22 kDa

WB Positive control:

HepG2, Hela, A549, COS7, Jurkat, MCF-7 cell lysates

WB Recommended dilution:

500-2000