小鼠抗MMP13单克隆抗体

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Applications:

WB, IHC, IF

Name of antibody:

MMP13

Immunogen:

Fusion protein of human MMP13

Full name:

matrix metallopeptidase 13 (MMP13)

Synonyms:

CLG3; MANDP1; MMP-13

SwissProt:

P45452

IHC positive control:

human pancreas tissue and human liver tissue; human lymph node tissue and carcinoma of human thyroid tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

54 kDa

WB Positive control:

HepG2, SVT2, A549, Jurkat and PC12 cell lysates

WB Recommended dilution:

500-2000