小鼠抗MLH1单克隆抗体

Background:

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).

Applications:

WB

Name of antibody:

MLH1

Immunogen:

Fusion protein of human MLH1

Full name:

mutL homolog 1

Synonyms:

FCC2; COCA2; HNPCC; hMLH1; HNPCC2

SwissProt:

P40692

WB Predicted band size:

85 kDa

WB Positive control:

293T, Jurkat and Hela cell lysates

WB Recommended dilution:

500-2000