小鼠抗MAP3K7单克隆抗体

Background:

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Applications:

WB

Name of antibody:

MAP3K7

Immunogen:

Fusion protein of human MAP3K7

Full name:

mitogen-activated protein kinase kinase kinase 7

Synonyms:

CSCF; FMD2; TAK1; MEKK7; TGF1a

SwissProt:

O43318

WB Predicted band size:

67 kDa

WB Positive control:

K562, Hela, MCF7, COS7, 3T3 and C6 cell lysates

WB Recommended dilution:

1000-5000