小鼠抗HSPBP1单克隆抗体

Background:

Hsp70-interacting protein (HspBP1) belongs to a family of eukaryotic proteins identified as nucleotide exchange factors for Hsp70, which exhibit varying degrees of compartment and species specificity. HspBP1 interferes with the CHIP-induced degradation of immature forms of the cystic fibrosis transmembrane conductance regulator (CFTR) and stimulates CFTR maturation. HspBP1 binds to Hsp70, inhibits its activity and promotes dissociation of nucleotides from the Hsp70 ATPase domain. It is a protein mainly expressed in heart and skeletal muscle.

Applications:

WB, IF, FC

Name of antibody:

HSPBP1

Immunogen:

Fusion protein of human HSPBP1

Full name:

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 (HSPBP1), transcript variant 1

Synonyms:

FES1

SwissProt:

Q9NZL4

WB Predicted band size:

39 kDa

WB Positive control:

A549, Jurkat cell lysates

WB Recommended dilution:

500-2000