小鼠抗HERPUD1单克隆抗体

Background:

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013].

Applications:

WB, IHC, IF

Name of antibody:

HERPUD1

Immunogen:

Fusion protein of human HERPUD1

Full name:

homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (HERPUD1), transcript variant 2

Synonyms:

HERP; Mif1; SUP

SwissProt:

Q15011

IHC positive control:

human pancreas tissue and carcinoma of human pancreas tissue; human endometrium tissue and human kidney tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

44 kDa

WB Positive control:

HepG2, Hela, SVT2, A549, Jurkat, MDCK, PC12, MCF-7 cell lysates

WB Recommended dilution:

500-2000