小鼠抗HDAC4(N-term)单克隆抗体

Background:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Applications:

WB, IP

Name of antibody:

HDAC4(N-term)

Immunogen:

Fusion protein of human HDAC4

Full name:

histone deacetylase 4

Synonyms:

HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A

SwissProt:

P56524

WB Predicted band size:

119 kDa

WB Positive control:

Jurkat, K562 and Hela cell lysates

WB Recommended dilution:

1000-5000