小鼠抗HDAC3单克隆抗体

Background:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Applications:

WB

Name of antibody:

HDAC3

Immunogen:

Fusion protein of human HDAC3

Full name:

histone deacetylase 3

Synonyms:

HD3; RPD3; RPD3-2

SwissProt:

O15379

WB Predicted band size:

49 kDa

WB Positive control:

THP-1, LNCAP, MCF7, PC12, 293, Jurkat, 3T3 and Hela cell lysates

WB Recommended dilution:

1000-5000