小鼠抗EIF4E单克隆抗体

Background:

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.

Applications:

WB

Name of antibody:

EIF4E

Immunogen:

Fusion protein of human EIF4E

Full name:

eukaryotic translation initiation factor 4E

Synonyms:

CBP; EIF4F; AUTS19; EIF4E1; eIF-4E; EIF4EL1

SwissProt:

P06730

WB Predicted band size:

25 kDa

WB Positive control:

Jurkat, Hela, MCF7, K562, C6, 3T3, PC12, HepG2, CHO-K1, Raji, Raw264.7 and Ramos cell lysates

WB Recommended dilution:

1000-5000