小鼠抗DPPA2单克隆抗体

Background:

DPPA2 (developmental pluripotency associated 2), also known as PESCRG1 (pluripotent embryonic stem cell-related gene 1 protein), is a 298 amino acid protein that localizes to the nucleus and contains one SAP domain. Expressed in embryonic stem cells, DPPA2 is thought to play a role in the maintenance of cell pluripotentiality and is associated with abnormal cell growth and cancer formation. The gene encoding DPPA2 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

Applications:

WB

Name of antibody:

DPPA2

Immunogen:

Fusion protein of human DPPA2

Full name:

developmental pluripotency associated 2 (DPPA2)

Synonyms:

CT100; ECAT15-2; PESCRG1

SwissProt:

Q7Z7J5

WB Predicted band size:

34 kDa

WB Positive control:

HepG2, Hela, MDCK, PC12, MCF-7 cell lysates

WB Recommended dilution:

500-2000