兔抗ABCB4多克隆抗体

Background:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Applications:

ELISA, IHC

Name of antibody:

ABCB4

Immunogen:

Synthetic peptide of human ABCB4

Full name:

ATP binding cassette subfamily B member 4

Synonyms:

GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3

SwissProt:

P21439

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

40-200