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英文名称： ZNF131 Antigen (Recombinant Protein)
别 名： zinc finger protein 131; ZBTB35; pHZ-10
相关类别：抗原
储 存： 冷冻（-20℃）
概 述
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Full name: |
zinc finger protein 131 |
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Synonyms: |
ZBTB35; pHZ-10 |
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Swissprot: |
P52739 |
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Gene Accession: |
BC035875 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF131 (Zinc finger protein 131) is a 623 amino acid nuclear protein that contains one BTB (POZ) domain and six C2H2-type zinc fingers. With predominant expression found in brain, it is likely that ZNF131 plays a role as a transcription regulator during development and organogenesis of the adult central nervous system. ZNF131 also represses ER? (Estrogen receptor alpha)-mediated transactivation by interrupting ER? binding to the estrogen-response element. There are two isoforms of ZNF131 that are produced as a result of alternative splicing events. |
