小鼠抗ARRB1单克隆抗体

Background:

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

Applications:

WB

Name of antibody:

ARRB1

Immunogen:

Fusion protein of human ARRB1

Full name:

arrestin beta 1

Synonyms:

ARB1; ARR1

SwissProt:

P49407

WB Predicted band size:

47 kDa

WB Positive control:

K562 and Hela cell lysates

WB Recommended dilution:

500-2000