兔抗CDKN1B(Phospho-Thr198)多克隆抗体

Background:

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Applications:

WB

Name of antibody:

CDKN1B(Phospho-Thr198)

Immunogen:

Peptide sequence around phosphorylation site of Threonine 198 (R-R-R(p)-Q-T) derived from Human p27 Kip1.

Full name:

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Synonyms：

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

SwissProt:

P46527

WB Predicted band size:

22 kDa

WB Positive control:

Hela cells lysates

WB Recommended dilution:

500-1000