兔抗CDK5R1多克隆抗体

Background:

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location.

Applications:

WB, IF

Name of antibody:

CDK5R1

Immunogen:

Synthesized peptide derived from internal of human CDK5R1.

Full name:

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Synonyms:

p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a

SwissProt:

Q15078

WB Predicted band size:

34 kDa

WB Positive control:

Rat brain tissue lysate

WB Recommended dilution:

500-3000

IF positive control:

Hela cells

IF Recommend dilution:

100-500