购物车
帮助
021-54845833/15800441009
中文名称：TEAD2 抗原（重组蛋白）
英文名称：TEAD2 Antigen (Recombinant Protein)
别 名： TEA domain transcription factor 2; ETF; TEF4; TEF-4; TEAD-2
储 存： 冷冻（-20℃）
相关类别：抗原
概 述
技术规格
|
Full name: |
TEA domain transcription factor 2 |
|
Synonyms: |
ETF; TEF4; TEF-4; TEAD-2 |
|
Swissprot: |
Q15562 |
|
Gene Accession: |
BC007556 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. |
