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中文名称： SEMA4D 抗原（重组蛋白）
英文名称： SEMA4D Antigen (Recombinant Protein)
别 名： semaphorin 4D; CD100; SEMAJ; coll-4; C9orf164; M-sema-G
储 存： 冷冻（-20℃）
相关类别：抗原
概 述
技术规格
|
Full name: |
semaphorin 4D |
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Synonyms: |
CD100; SEMAJ; coll-4; C9orf164; M-sema-G |
|
Swissprot: |
Q92854 |
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Gene Accession: |
BC054500 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA. |
