兔抗WWOX(Phospho-Tyr33) 多克隆抗体

Background:

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Applications:

WB, IHC

Name of antibody:

WWOX(Phospho-Tyr33)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 33 (W-V-Y(p)-Y-A) derived from Human WWOX.

Full name:

WW domain containing oxidoreductase

Synonyms：

FOR; WOX1; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E

SwissProt:

Q96KM3

IHC positive control:

Human colon carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

47 kDa

WB Positive control:

HepG2 cells lysates treated with PMA

WB Recommended dilution:

500-1000