兔抗CASR多克隆抗体

Background:

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Applications:

ELISA, IHC

Name of antibody:

CASR

Immunogen:

Fusion protein of human CASR

Full name:

calcium sensing receptor

Synonyms:

CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1

SwissProt:

P41180

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer and Human liver cancer

IHC Recommend dilution:

50-300