兔抗CACNB4多克隆抗体

Background:

This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

CACNB4

Immunogen:

Synthetic peptide of human CACNB4

Full name:

calcium voltage-gated channel auxiliary subunit beta 4

Synonyms:

EA5; EJM; CAB4; EIG9; EJM4; EJM6; CACNLB4

SwissProt:

O00305

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

58 kDa

WB Positive control:

Mouse brain tissue lysate

WB Recommended dilution:

200-1000