兔抗CA9多克隆抗体

Background:

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

Applications:

ELISA, WB, IHC

Name of antibody:

CA9

Immunogen:

Fusion protein of human CA9

Full name:

carbonic anhydrase IX

Synonyms：

MN; CAIX

SwissProt:

Q16790

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colon cancer and human liver cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

50 kDa

WB Positive control:

Human gastric carcinoma tissue lysate

WB Recommended dilution:

500-2000