兔抗BRCA2多克隆抗体

Background:

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Applications:

ELISA, IHC

Name of antibody:

BRCA2

Immunogen:

Synthetic peptide of humanBRCA2

Full name:

Breast cancer type 2 susceptibility protein

Synonyms：

FAD, FACD, FAD1, GLM3, BRCC2, FANCB, FANCD, PNCA2, FANCD1, BROVCA2

SwissProt:

P51587

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human lung cancer

IHC Recommend dilution:

25-100