兔抗AXIN1多克隆抗体

Background:

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.

Applications:

ELISA, IHC

Name of antibody:

AXIN1

Immunogen:

Synthetic peptide of human AXIN1

Full name:

axin 1

Synonyms：

AXIN; PPP1R49

SwissProt:

O15169

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human lung cancer

IHC Recommend dilution:

25-100