兔抗ATF2(Phospho-Ser472) 多克隆抗体

Background:

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

Applications:

IHC

Name of antibody:

ATF2(Phospho-Ser472)

Immunogen:

Peptide sequence around phosphorylation site of Serine 472 (E-A-V(p)-A-T) derived from Human ATF-2.

Full name:

activating transcription factor 2

Synonyms：

HB16; CREB2; TREB7; CREB-2; CRE-BP1

SwissProt:

P15336

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100