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021-54845833/15800441009
中文名称： 兔抗WAPL多克隆抗体
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Background: |
WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and is expressed as two alternatively spliced isoforms, one of which localizes to the nucleus. Expressed in an isoform-dependent manner in heart, skeletal muscle and uterine cervix tumor tissue, WAPL is involved in sister-chromatid adhesion and overall cell growth, specifically playing a role in the development and metastasis of cancerous tissue. The gene encoding WAPL maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
WAPL |
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Immunogen: |
Synthetic peptide of human WAPL |
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Full name: |
WAPL cohesin release factor |
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Synonyms: |
FOE; WAPAL; KIAA0261 |
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SwissProt: |
Q7Z5K2 |
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ELISA Recommended dilution: |
500-1000 |
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IHC positive control: |
Human brain and human ovarian cancer |
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IHC Recommend dilution: |
20-100 |
