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Background:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1.
Applications:
WB
Name of antibody:
VAV1(Ab-174)
Immunogen:
Synthesized non-phosphopeptide derived from human VAV1 around the phosphorylation site of tyrosine 174 (E-I-Y-E-D).
Full name:
vav 1 guanine nucleotide exchange factor
Synonyms：
VAV
SwissProt:
P15498
WB Predicted band size:
98 kDa
WB Positive control:
Jurkat cells lysate
WB Recommended dilution:
500-3000
