兔抗APOB多克隆抗体

IHC Recommend dilution:

15-50

IHC positive control:

Human colon cancer and Human thyroid cancer

ELISA Recommended dilution:

1000-5000

SwissProt:

P04114

Synonyms：

FLDB; LDLCQ4

Full name:

apolipoprotein B (including Ag(x) antigen)

Immunogen:

Synthetic peptide of human APOB

Name of antibody:

APOB

Applications:

ELISA, IHC

Background:

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.