Background: |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. |
Applications: |
WB, IF |
Name of antibody: |
TP53 (Phospho-Ser33) |
Immunogen: |
Synthetic peptide of human TP53 (Phospho-Ser33) |
Full name: |
tumor protein p53 (Phospho-Ser33) |
Synonyms: |
P53; BCC7; LFS1; TRP53 |
SwissProt: |
P04637 |
WB Predicted band size: |
44 kDa |
WB Positive control: |
HT29 cells |
WB Recommended dilution: |
500-1000 |
IF Positive control: |
Hela cells |
IF Recommended dilution |
100-200 |