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021-54845833/15800441009
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Background: |
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
TNK2 |
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Immunogen: |
Synthetic peptide of human TNK2 |
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Full name: |
tyrosine kinase, non-receptor, 2 |
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Synonyms： |
ACK, ACK1, ACK-1, p21cdc42Hs |
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SwissProt: |
Q07912 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human breast cancer and Human liver cancer |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
119 kDa |
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WB Positive control: |
231 cells |
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WB Recommended dilution: |
1000-5000 |
