Background: |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Applications: |
ELISA, IHC |
Name of antibody: |
TNFRSF8 |
Immunogen: |
Synthetic peptide of human TNFRSF8 |
Full name: |
tumor necrosis factor receptor superfamily, member 8 |
Synonyms: |
CD30; Ki-1; D1S166E |
SwissProt: |
P28908 |
ELISA Recommended dilution: |
1000-5000 |
IHC positive control: |
Human Lymphoma and Human thyroid cancer |
IHC Recommend dilution: |
50-200 |