Background: |
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. |
Applications: |
ELISA, IHC |
Name of antibody: |
TMEM123 |
Immunogen: |
Fusion protein of human TMEM123 |
Full name: |
transmembrane protein 123 |
Synonyms: |
KCT3; PORMIN; PORIMIN |
SwissProt: |
Q8N131 |
ELISA Recommended dilution: |
2000-10000 |
IHC positive control: |
Human liver cancer |
IHC Recommend dilution: |
30-150 |