兔抗TLR3多克隆抗体

Background:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Applications:

ELISA, WB

Name of antibody:

TLR3

Immunogen:

Fusion protein of human TLR3

Full name:

toll-like receptor 3

Synonyms：

CD283; IIAE2

SwissProt:

O15455

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

104 kDa

WB Positive control:

Raji and K562 cells

WB Recommended dilution:

500-2000