兔抗STK3/4(Phospho-Thr183)多克隆抗体

Background:

STK3 encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. STK4 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.

Applications:

WB

Name of antibody:

STK3/4(Phospho-Thr183)

Immunogen:

Synthetic peptide of human STK3/4

Full name:

serine/threonine kinase 3/4

Synonyms:

KRS1; MST2; KRS2; MST1; YSK3

SwissProt:

Q13188/Q13043

WB Predicted band size:

56 kDa

WB Positive control:

293 cells

WB Recommended dilution:

500-1000