兔抗GRIN2B(Ab-1303)多克隆抗体

Background:

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death By similarity.

Applications:

WB

Name of antibody:

GRIN2B(Ab-1303)

Immunogen:

Synthesized non-phosphopeptide derived from human GRIN2B around the phosphorylation site of serine 1303 (Q-H-S(p)-Y-D).

Full name:

glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Synonyms：

MRD6; NR2B; hNR3; GluN2B; NMDAR2B

SwissProt:

Q13224

WB Predicted band size:

166 kDa

WB Positive control:

NIH/3T3 cells lysates

WB Recommended dilution:

500-3000