兔抗PRKAB1(Phospho-Ser181)多克隆抗体

Background:

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol.

Applications:

WB

Name of antibody:

PRKAB1(Phospho-Ser181)

Immunogen:

Peptide sequence around phosphorylation site of Serine 181 (L-S-S(p)-S-P) derived from Human AMPK β1.

Full name:

protein kinase, AMP-activated, beta 1 non-catalytic subunit

Synonyms：

AMPK; HAMPKb

SwissProt:

Q9Y478

WB Predicted band size:

30 kDa

WB Positive control:

Rat kidney tissue lysates

WB Recommended dilution:

500-1000