兔抗PNRC2多克隆抗体

Background:

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).

Applications:

ELISA, IHC

Name of antibody:

PNRC2

Immunogen:

Fusion protein of human PNRC2

Full name:

proline rich nuclear receptor coactivator 2

SwissProt:

Q9NPJ4

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer and Human colorectal cancer

IHC Recommend dilution:

50-300